Introduction

The research in our laboratory focuses on understanding and treating neuropsychiatric and neurodegenerative disorders. To achieve this, we employ a variety of approaches, including induced pluripotent stem cell (iPSC) and organoid technologies, electrophysiology, fluorescence imaging, opto-/chemogenetics, animal behavior analysis, and multi-omics profiling.

Currently, our lab conducts four major lines of research:

1) Combining iPSC/organoid and animal models to investigate mental disordersmental disorders, particularly bipolar disorder and depression;

2) Using brain organoids to develop transplantation therapies for neurodegenerative diseases such as Parkinson’s disease (PD)

3) Employing vascularized brain organoids to study cerebrovascular diseases;

4) Developing new astrocyte-to-neuron transdifferentiation techniques for the treatment of neurodegenerative diseases.

Our overarching goal is to translate our research findings into clinical applications for the diagnosis and treatment of neurological disorders.